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Ductile extension of 3-D external circumferential cracks in pipe structures

Wuchao YANG, Xudong QIAN

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 294-303 doi: 10.1007/s11709-011-0115-9

Abstract: external circumferential cracks in the wall of a steel pipe under remote tension, using a damage-mechanism modelfracture resistance along the 3-D semi-elliptical crack front is computed from the calibrated cell modelin the near-tip stress-strain fields, this study demonstrates that an equivalent 2-D axi-symmetric model

Keywords： ductile fracture     computational cell method     G-T model     J-R curve    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9.The splicing effect of c.1210-3C>G was verified via minigene assay in vitro, indicating that wild-type10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence causedOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Ensemble unit and AI techniques for prediction of rock strain

Pradeep T; Pijush SAMUI; Navid KARDANI; Panagiotis G ASTERIS

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 858-870 doi: 10.1007/s11709-022-0831-3

Abstract: The GBM model achieved 98.16% and 99.98% prediction accuracy (in terms of values of R2model, based on the experimental data, has the potential to be a new option for engineers to

Keywords： prediction     strain     ensemble unit     rank analysis     error matrix    

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Sustainable intensification of agriculture in Africa

Antonius G.T. SCHUT, Ken E. GILLER

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 4,   Pages 371-375 doi: 10.15302/J-FASE-2020357

Abstract: Sustainable intensification is a key component of agricultural development in Africa, urgently needed to wean the continent off foreign food supply and to limit agricultural farmland expansion. It is expected that a relatively small fraction of farmers will adopt fertilizer technology, as profits in current economic settings are relatively small while risks are considerable with varying prices and uncertain yield responses. Many smallholders depend on off-farm income and local markets for food supply. Structural adjustments are therefore needed to allow management of larger units of land by trained farmers willing to take this opportunity, while recognizing land right sensitivities. There are large opportunities for African commodity crops to improve food security, including cassava and East African highland banana that strongly respond to fertilizer with limited environmental risks under good management. This requires investments in better functioning markets, local fertilizer production facilities that can produce regional crop blends and cost-efficient distribution networks, providing balanced fertilizers for African farmers.

Keywords： Green Revolution     Manihot esculenta     Musa acuminata     sub-Saharan Africa    

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randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: bacillus Calmette-Guerin (BCG) could reduce recurrence after transurethral resection of tumor 1 grade 3 (T1G3resection plus another treatment on the treatment results in patients with superficial bladder cancer of T1G3Both the fixed effects model and random effects model were applied, and the odds ratio () with its 95%The randomized model combined effect of Pasteur F and other strains were 0.50 (95% CI 0.26 to 0.95,resection of bladder tumor (TURBT) is an effective conservative treatment for preventing recurrence of T1G3
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REINTEGRATION OF CROP-LIVESTOCK SYSTEMS IN EUROPE: AN OVERVIEW

Antonius G. T. SCHUT, Emily C. COOLEDGE, Marc MORAINE, Gerrie W. J. VAN DE VEN, Davey L.

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 1,   Pages 111-129 doi: 10.15302/J-FASE-2020373

Abstract: Ongoing specialization of crop and livestock systems provides socioeconomic benefits to the farmer but has led to greater externalization of environmental costs when compared to mixed farming systems. Better integration of crop and livestock systems offers great potential to rebalance the economic and environmental trade-offs in both systems. The aims of this study were to analyze changes in farm structure and review and evaluate the potential for reintegrating specialized intensive crop and livestock systems, with specific emphasis on identifying the co-benefits and barriers to reintegration. Historically, animals were essential to recycle nutrients in the farming system but this became less important with the availability of synthetic fertilisers. Although mixed farm systems can be economically attractive, benefits of scale combined with socio-economic factors have resulted in on-farm and regional specialization with negative environmental impacts. Reintegration is therefore needed to reduce nutrient surpluses at farm, regional and national levels, and to improve soil quality in intensive cropping systems. Reintegration offers practical and cost-effective options to widen crop rotations and promotes the use of organic inputs and associated benefits, reducing dependency on synthetic fertilisers, biocides and manure processing costs. Circular agriculture goes beyond manure management and requires adaptation of both food production and consumption patterns, matching local capacity to produce with food demand. Consequently, feed transport, greenhouse gas emissions, nutrient surpluses and nutrient losses to the environment can be reduced. It is concluded that reintegration of specialized farms within a region can provide benefits to farmers but may also lead to further intensification of land use. New approaches within a food system context offer alternatives for reintegration, but require strong policy incentives which show clear, tangible and lasting benefits for farmers, the environment and the wider community.

Keywords： circular agriculture     coupled farming systems     mixed farming     specialised farming systems     GHG    

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A multi-scale model for CO

G. X. WANG, X. R. WEI, V. RUDOLPH, C. T. WEI, Y. QIN

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11705-009-0138-0

Abstract: This paper presents a multi-scale model to simulate the multicomponent gas diffusion and flow in bulkThe model is developed based on a bi-dispersed structure model by assuming that coal consists of microporousThe bi-disperse diffusion theory and the Maxwell-Stefan approach were incorporated in the model, providingIn the model, the counter diffusion process is numerically coupled with the flow of the mixture gasesThe model was validated by both experimental data from literature and our CO flush tests, and shows

Keywords： multi-scale model     gas transport     coal     coalbed methane     CO2 sequestration    

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Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through Engineering Invention, Research, and Development

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M.Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Engineering 2021, Volume 7, Issue 2,   Pages 141-143 doi: 10.1016/j.eng.2020.06.020

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Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device Article

Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Engineering 2015, Volume 1, Issue 3,   Pages 344-350 doi: 10.15302/J-ENG-2015077

Abstract: These data were used to build an empirical predictive temporal model of distribution volume as a function

Keywords： near-infrared laser     thermochemotherapy     agarose     photothermal heating     micro-catheter     malignant glioma    

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State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 404-416 doi: 10.1007/s11684-020-0743-3

Abstract: A number of developed countries are rapidly turning into super-aged societies. Consequently, the demand for reduced surgical invasiveness and enhanced efficiency in the medical field has increased due to the need to reduce the physical burden on older patients and shorten their recovery period. Intelligent surgical robot systems offer high precision, high safety, and reduced invasiveness. This paper presents a review of current intelligent surgical robot systems. The history of robots and three types of intelligent surgical robots are discussed. The problems with current surgical robot systems are then analyzed. Several aspects that should be considered in designing new surgical systems are discussed in detail. The paper ends with a summary of the work and a discussion of future prospects for surgical robot development.

Keywords： robot history     medical robot     surgical robot     radiofrequency ablation     organ model    

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Predictive Functional Control Based on Fuzzy Model for HVAC Systems

Lu Hongli,Jia Lei,Wang Lei,Gao Rui

Strategic Study of CAE 2006, Volume 8, Issue 9,   Pages 65-68

Abstract: A novel predictive functional control strategy based on Takagi-Sugeno fuzzy model was developed in orderThe T - S fuzzy model of controlled process was obtained using the least squares method, then basingon the fuzzy T - S global linear predictive model, the process was controlled by the predictive functionalFinally, the simulation results in HVAC systems control application showed that the proposed fuzzy model

Keywords： T-S fuzzy model     predictive functional control     least squares method     HVAC systems    

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R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 932-945 doi: 10.1007/s11684-022-0963-9

Abstract: The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensionalMeanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCCR158Q/G212S. mice an optimal mouse model for further study of GS.These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of

Keywords： Gitelman syndrome     mouse model     compound heterozygous     hypokalemia     Slc12a3    

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PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing Article

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Engineering 2022, Volume 15, Issue 8,   Pages 67-77 doi: 10.1016/j.eng.2022.02.013

Abstract: Despite the notable C-to-T conversions, a high proportion of undesired byproducts exists with St1Cas9uracil DNA glycosylase (UNG) fusion, yielding two new base editors (CTBE and CGBE) capable of C-to-Tor C-to-G conversions with dramatically enhanced editing product purity and multiplexed editing capacity

Keywords： CRISPR     Cas9     Mycobacterium tuberculosis     Genome editing     Base editing    

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Simultaneous saccharification and fermentation of wheat bran flour into ethanol using coculture of amylotic

Manikandan, T. Viruthagiri

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 240-249 doi: 10.1007/s11705-009-0205-6

Abstract: optimum values of substrate concentration, pH, temperature, and enzyme concentration were found to be 200 g/equivalent to 6% ( / ) initial starch concentration gave the highest ethanol concentration of 23.1 g/The growth kinetics was modeled using Monod model and Logistic model and product formation kinetics usingLeudeking-Piret model.

Keywords： and fermentation (SSF)     starch     coculture fermentation     statistical experimental design     bioethanol     Monod model    

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Optimal Antibody Purification Strategies Using Data-Driven Models Article

Songsong Liu, Lazaros G. Papageorgiou

Engineering 2019, Volume 5, Issue 6,   Pages 1077-1092 doi: 10.1016/j.eng.2019.10.011

Abstract:

This work addresses the multiscale optimization of the purification processes of antibody fragments. Chromatography decisions in the manufacturing processes are optimized, including the number of chromatography columns and their sizes, the number of cycles per batch, and the operational flow velocities. Data-driven models of chromatography throughput are developed considering loaded mass, flow velocity, and column bed height as the inputs, using manufacturing-scale simulated datasets based on microscale experimental data. The piecewise linear regression modeling method is adapted due to its simplicity and better prediction accuracy in comparison with other methods. Two alternative mixed-integer nonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibody purification process, incorporating the data-driven models. These MINLP models are then reformulated as mixed-integer linear programming (MILP) models using linearization techniques and multiparametric disaggregation. Two industrially relevant cases with different chromatography column size alternatives are investigated to demonstrate the applicability of the proposed models.

Keywords： purification     Multiscale optimization     Antigen-binding fragment     Mixed-integer programming     Data-driven model    

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Title Author Date Type Operation

Ductile extension of 3-D external circumferential cracks in pipe structures

Wuchao YANG, Xudong QIAN

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Ensemble unit and AI techniques for prediction of rock strain

Pradeep T; Pijush SAMUI; Navid KARDANI; Panagiotis G ASTERIS

Journal Article

Sustainable intensification of agriculture in Africa

Antonius G.T. SCHUT, Ken E. GILLER

Journal Article

randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

REINTEGRATION OF CROP-LIVESTOCK SYSTEMS IN EUROPE: AN OVERVIEW

Antonius G. T. SCHUT, Emily C. COOLEDGE, Marc MORAINE, Gerrie W. J. VAN DE VEN, Davey L.

Journal Article

A multi-scale model for CO

G. X. WANG, X. R. WEI, V. RUDOLPH, C. T. WEI, Y. QIN

Journal Article

Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through Engineering Invention, Research, and Development

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M.Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Journal Article

Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device

Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Journal Article

State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

Journal Article

Predictive Functional Control Based on Fuzzy Model for HVAC Systems

Lu Hongli,Jia Lei,Wang Lei,Gao Rui

Journal Article

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

Journal Article

PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Journal Article

Simultaneous saccharification and fermentation of wheat bran flour into ethanol using coculture of amylotic

Manikandan, T. Viruthagiri

Journal Article

Optimal Antibody Purification Strategies Using Data-Driven Models

Songsong Liu, Lazaros G. Papageorgiou

Journal Article